Lysophosphatidic Acid and Sphingosine-1-Phosphate in Pluripotent Stem Cells

Abstract

Lipids are the major components of biological membranes, playing a role in cell architecture and integrity but also in signaling. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are signaling lipids known to exert pleiotropic effects in various cell types, including during development and disease. They have also been described as potent mediators of stem cell behavior. In this chapter, we review the current knowledge on these major signaling lipids by focusing on pluripotent stem cells. Their impact on pluripotency will be described.